Types of GLP‑1 Drugs & Brands

What is the difference between GLP‑1 compounds like semaglutide, tirzepatide, and retatrutide?

Semaglutide targets only the GLP‑1 receptor. Tirzepatide binds GLP‑1 plus GIP, and investigational retatrutide adds glucagon receptors. Each extra receptor layer improves weight and glucose control but can shift side‑effect patterns and dose‑ramp schedules.

Which brands correspond to each GLP‑1 compound?

Semaglutide = Wegovy (weight loss) and Ozempic/Rybelsus (diabetes).

Tirzepatide = Zepbound (weight loss) and Mounjaro (diabetes).

Liraglutide = Saxenda (weight loss) and Victoza (diabetes).

Retatrutide is still in clinical trials.

Which GLP‑1 drugs are FDA‑approved for weight loss versus diabetes?

Weight loss: Wegovy, Zepbound, Saxenda.

Type 2 diabetes: Ozempic, Rybelsus, Mounjaro, Trulicity, Victoza, Byetta, Bydureon.

Some clinicians lawfully use the diabetes versions off‑label for weight management when cost or access is better.

What does “indication” mean for a GLP‑1 medication?

An indication is the specific condition the FDA evaluated and approved the drug to treat. For example, Wegovy’s indication is chronic weight management in adults with obesity or overweight plus at least one weight‑related condition.