Overview of GLP‑1 Side‑Effects

How soon after my first GLP‑1 injection will side effects start?

Mild nausea, early fullness, or fatigue usually appear within 24–48 hours because stomach emptying slows quickly. Roughly half of users feel no side effects in week 1. Others report transient digestive changes that calm as the body adapts.

How common are side effects on GLP‑1  medications, and how do most users avoid them?

Clinical trials show about 60 % of users experience at least one mild GI symptom, yet fewer than 10 % discontinue treatment due to side effects. With gradual dose titration, most people complete therapy with manageable or no persistent side effects.

Do GLP‑1 side effects get worse at each dose increase?

They can briefly intensify as plasma levels rise, which is why prescribers titrate every four weeks. If symptoms flare, physicians may extend a dose phase or step back until tolerance improves.