Tummy problems on GLP‑1

Why does GLP‑1 therapy cause nausea, bloating, constipation, or diarrhea?

GLP‑1 receptor activation slows gastric emptying and intestinal motility, allowing food to sit longer in the stomach. The same mechanism that increases fullness also changes water absorption in the colon, creating either harder stools or, less commonly, loose stools.

What is the best meal timing to reduce GLP‑1‑related nausea?

Plan four small, protein‑forward meals spaced 3–4 hours apart. Inject in the morning so peak drug action aligns with daylight eating, and keep evening meals lighter to avoid overnight stomach fullness that triggers morning nausea.

What are some options to reduce my GLP‑1 nausea?

Start with hydration, slow eating, ginger capsules (1 g daily), sugar‑free peppermint tea, or acupressure wristbands. If ineffective, your prescriber may add ondansetron or low‑dose metoclopramide. Always report severe or worsening nausea promptly.